Professor Grant Collins

+61 2 6268 8077
+61 2 6268 8017

LOCATION

Room 214 PEMS North (Bldg 22) School of Physical, Environmental and Mathematical Sciences, UNSW Canberra, Australian Defence Force Academy, PO Box 7916, Canberra BC ACT 2610, AUSTRALIA

  • PUBLICATIONS

Book Chapters

Collins JG; Smith JA; Li F; Keene FR, 2013, 'Noncovalent DNA binding of metal complexes', in Reedijk J; Poeppelmeier K (ed.), Comprehensive Inorganic Chemistry II (Second Edition): From Elements to Applications, Elsevier, pp. 709 - 750, http://dx.doi.org/10.1016/B978-0-08-097774-4.00329-6

Day AI; Collins JG, 2012, 'Cucurbituril Receptors and Drug Delivery', in Gale PA; Steed JW (ed.), Supramolecular Chemistry: From Molecules to Nanomaterials, edn. Original, John Wiley & Sons, Chichester, UK, pp. 983 - 1000

Hicks M; Orkey NU; Pisani M; Collins JG; Wheate NJ; Aldrich-Wright JR, 2011, 'Using spectroscopic techniques to examine drug-DNA interactions', in Wanunu M; Tor Y (ed.), Methods for Studying Nucleic Acid/Drug Interactions, CRC Press, pp. 3 - 42

Buck DP; Collins JG, 2011, 'NMR Studies of Metallointercalator-DNA Interactions', in AldrichWright J (ed.), METALLOINTERCALATORS: SYNTHESIS AND TECHNIQUES TO PROBE THEIR INTERACTIONS WITH BIOMOLECULES, SPRINGER-VERLAG WIEN, pp. 143 - 157, http://dx.doi.org/10.1007/978-3-211-99079-7_6

Buck DP; Collins JG, 2011, 'NMR Studies of Metallointercalator-DNA Interactions', in Aldrich Wright JR (ed.), Metallointercalators - Synthesis and Techniques to Probe Their Interactions with Biomolecules, edn. 1st, Springer, New York, pp. 143 - 157, http://dx.doi.org/10.1007/978-3-211-99079-7

Smith JA; Collins JG; Keene FR, 2009, 'Groove-binding ruthenium(II)complexes as probes of DNA recognition', in Hadjiliadis N; Sletten E (ed.), Metal Complex-DNA Interactions, edn. Original, Wiley, UK, pp. 319 - 346

Journal articles

Sun B; Sundaraneedi MK; Southam HM; Poole RK; Musgrave IF; Keene FR; Collins JG, 2019, 'Synthesis and biological properties of tetranuclear ruthenium complexes containing the bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane ligand', Dalton Transactions, vol. 48, pp. 14505 - 14515, http://dx.doi.org/10.1039/c9dt03221e

Flint KL; Collins JG; Bradley SJ; Smith TA; Sumby CJ; Keene FR, 2019, 'Synthesis and Characterisation of Helicate and Mesocate Forms of a Double-Stranded Diruthenium(II) Complex of a Di(terpyridine) Ligand', Australian Journal of Chemistry, vol. 72, pp. 762 - 768, http://dx.doi.org/10.1071/CH19220

Sun B; Musgrave IF; Day AI; Heimann K; Keene FR; Collins JG, 2018, 'Eukaryotic cell toxicity and HSA binding of [Ru(Me 4 phen)(bb 7 )] 2+ and the effect of encapsulation in cucurbit[10]uril', Frontiers in Chemistry, vol. 6, http://dx.doi.org/10.3389/fchem.2018.00595

Liu X; Sun B; Kell REM; Southam HM; Butler JA; Li X; Poole RK; Keene FR; Collins JG, 2018, 'The Antimicrobial Activity of Mononuclear Ruthenium(II) Complexes Containing the dppz Ligand', ChemPlusChem, vol. 83, pp. 643 - 650, http://dx.doi.org/10.1002/cplu.201800042

Sun B; Southam HM; Butler JA; Poole RK; Burgun A; Tarzia A; Keene FR; Collins JG, 2018, 'Synthesis, isomerisation and biological properties of mononuclear ruthenium complexes containing the bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane ligand', Dalton Transactions, vol. 47, pp. 2422 - 2434, http://dx.doi.org/10.1039/c7dt04595f

Li X; Gorle AK; Sundaraneedi MK; Keene FR; Collins JG, 2018, 'Kinetically-inert polypyridylruthenium(II) complexes as therapeutic agents', Coordination Chemistry Reviews, vol. 375, pp. 134 - 147, http://dx.doi.org/10.1016/j.ccr.2017.11.011

Sundaraneedi M; Eichenberger RM; Al-Hallaf R; Yang D; Sotillo J; Rajan S; Wangchuk P; Giacomin PR; Keene FR; Loukas A; Collins JG; Pearson MS, 2018, 'Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases', International Journal for Parasitology: Drugs and Drug Resistance, vol. 8, pp. 1 - 7, http://dx.doi.org/10.1016/j.ijpddr.2017.11.005

Sundaraneedi MK; Ammit AJ; Tedla BA; Pearson MS; Loukas A; Keene FR; Collins JG, 2017, 'Tetranuclear Polypyridylruthenium(II) Complexes as Inhibitors and Down-Regulators of Phosphatase Enzymes', ChemistrySelect, vol. 2, pp. 10668 - 10672, http://dx.doi.org/10.1002/slct.201702118

Sundaraneedi MK; Tedla BA; Eichenberger RM; Becker L; Pickering D; Smout MJ; Rajan S; Wangchuk P; Keene FR; Loukas A; Collins JG; Pearson MS, 2017, 'Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases', PLoS Neglected Tropical Diseases, vol. 11, http://dx.doi.org/10.1371/journal.pntd.0006134

Li F; Gorle AK; Ranson M; Vine KL; Kinobe R; Feterl M; Warner JM; Keene FR; Collins JG; Day AI, 2017, 'Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: And a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril', Organic and Biomolecular Chemistry, vol. 15, pp. 4172 - 4179, http://dx.doi.org/10.1039/c7ob00724h

Konda SK; Maliki R; McGrath S; Parker BS; Robinson T; Spurling A; Cheong A; Lock P; Pigram PJ; Phillips DR; Wallace L; Day AI; Collins JG; Cutts SM, 2017, 'Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer', ACS Medicinal Chemistry Letters, vol. 8, pp. 538 - 542, http://dx.doi.org/10.1021/acsmedchemlett.7b00090

Gorle AK; Bottomley AL; Harry EJ; Collins JG; Keene FR; Woodward CE, 2017, 'DNA condensation in live E. coli provides evidence for transertion', Molecular BioSystems, vol. 13, pp. 677 - 680, http://dx.doi.org/10.1039/c6mb00753h

Weber DK; Sani M-A; Downton MT; Separovic F; Keene FR; Collins JG, 2016, 'Membrane Insertion of a Dinuclear Polypyridylruthenium(II) Complex Revealed by Solid-State NMR and Molecular Dynamics Simulation: Implications for Selective Antibacterial Activity', Journal of the American Chemical Society, vol. 138, pp. 15267 - 15277, http://dx.doi.org/10.1021/jacs.6b09996

Konda SK; Kelso C; Medan J; Sleebs BE; Phillips DR; Cutts SM; Collins JG, 2016, 'Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major–minor groove cross-linked adducts', Org. Biomol. Chem., vol. 14, pp. 10217 - 10221, http://dx.doi.org/10.1039/C6OB02100J

Li X; Heimann K; Dinh XT; Keene FR; Collins JG, 2016, 'Biological processing of dinuclear ruthenium complexes in eukaryotic cells', Molecular BioSystems, vol. 12, pp. 3032 - 3045, http://dx.doi.org/10.1039/c6mb00431h

Gorle AK; Li X; Primrose S; Li F; Feterl M; Kinobe RT; Heimann K; Warner JM; Richard Keene F; Grant Collins J, 2016, 'Oligonuclear polypyridylruthenium(II) complexes: Selectivity between bacteria and eukaryotic cells', Journal of Antimicrobial Chemotherapy, vol. 71, pp. 1547 - 1555, http://dx.doi.org/10.1093/jac/dkw026

Li X; Heimann K; Li F; Warner JM; Richard Keene F; Grant Collins J, 2016, 'Dinuclear ruthenium(II) complexes containing one inert metal centre and one coordinatively-labile metal centre: Syntheses and biological activities', Dalton Transactions, vol. 45, pp. 4017 - 4029, http://dx.doi.org/10.1039/c5dt04885k

Konda SK; Kelso C; Pumuye PP; Medan J; Sleebs BE; Cutts SM; Phillips DR; Collins G, 2016, 'Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA', Org. Biomol. Chem., vol. 14, pp. 4728 - 4738, http://dx.doi.org/10.1039/C6OB00561F

Pandrala M; Sundaraneedi MK; Ammit AJ; Woodward CE; Wallace L; Keene FR; Collins G, 2015, 'Differential Anticancer Activities of the Geometric Isomers of Dinuclear Iridium(III) Complexes', European Journal of Inorganic Chemistry, vol. 2015, pp. 5694 - 5701, http://dx.doi.org/10.1002/ejic.201501069

Konda SK; Wang H; Cutts SM; Phillips DR; Collins JG, 2015, 'Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures', Org. Biomol. Chem., vol. 13, pp. 5972 - 5982, http://dx.doi.org/10.1039/C5OB00526D

Gorle AK; Feterl M; Warner JM; Primrose S; Constantinoiu CC; Keene FR; Collins G, 2015, 'Mononuclear Polypyridylruthenium(II) Complexes with High Membrane Permeability in Gram-Negative Bacteria-in particular Pseudomonas aeruginosa', Chemistry (Weinheim an der Bergstrasse, Germany), vol. 21, pp. 10472 - 10481, http://dx.doi.org/10.1002/chem.201500385

Li F; Collins JG; Keene FR, 2015, 'Ruthenium complexes as antimicrobial agents', Chem. Soc. Rev., vol. 44, pp. 2529 - 2542, http://dx.doi.org/10.1039/C4CS00343H

Li X; Gorle AK; Ainsworth TD; Heimann K; Woodward CE; collins J; Richard Keene F, 2015, 'RNA and DNA binding of inert oligonuclear ruthenium( ii ) complexes in live eukaryotic cells', Dalton Trans., vol. 44, pp. 3594 - 3603, http://dx.doi.org/10.1039/C4DT02575J

Upadhyay PJ; Zhou F; Collins G; Wheate NJ, 2014, 'TARGETED DELIVERY OF PLATINUM DRUGS TO TUMOURS USING CARRIER DNA-TETHERED APTAMERS', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, vol. 10, pp. 42 - 43, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100118&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Gorle AK; Feterl M; Warner JM; Wallace L; Keene FR; Collins JG, 2014, 'Tri- and tetra-nuclear polypyridyl ruthenium( ) complexes as antimicrobial agents', Dalton Trans., vol. 43, pp. 16713 - 16725, http://dx.doi.org/10.1039/C4DT02139H

Gorle AK; Ammit AJ; Wallace L; Keene FR; Collins JG, 2014, 'Multinuclear ruthenium( ) complexes as anticancer agents', New Journal of Chemistry, vol. 38, pp. 4049 - 4059, http://dx.doi.org/10.1039/C4NJ00545G

Li F; Harry EJ; Bottomley AL; Edstein MD; Birrell GW; Woodward CE; Keene FR; Collins JG, 2014, 'Dinuclear ruthenium(ii) antimicrobial agents that selectively target polysomes in vivo', Chemical Science, vol. 5, pp. 685 - 693, http://dx.doi.org/10.1039/c3sc52166d

Li F; Feterl M; Warner JM; Keene FR; Collins JG, 2013, 'Dinuclear polypyridylruthenium(II) complexes: flow cytometry studies of their accumulation in bacteria and the effect on the bacterial membrane', Journal of Antimicrobial Chemotherapy, vol. 68, pp. 2825 - 2833, http://dx.doi.org/10.1093/jac/dkt279

Pandrala M; Li F; Wallace L; Steel PJ; Moore B; Autschbach J; Collins JG; Keene FR, 2013, 'Iridium(iii) Complexes Containing 1,10-Phenanthroline and Derivatives: Synthetic, Stereochemical, and Structural Studies, and their Antimicrobial Activity', Australian Journal of Chemistry, vol. 66, pp. 1065 - 1073, http://dx.doi.org/10.1071/CH13264

Pandrala M; Li F; Feterl M; Mulyana Y; Warner JM; Wallace L; Keene FR; Collins JG, 2013, 'Chlorido-containing ruthenium(ii) and iridium(iii) complexes as antimicrobial agents', Journal of the Royal Chemical Society, Dalton Transactions, vol. 42, pp. 4686 - 4694, http://dx.doi.org/10.1039/c3dt32775b

Li F; Feterl M; Warner JM; Day AI; Keene FR; Collins JG, 2013, 'Protein binding by dinuclear polypyridyl ruthenium(ii) complexes and the effect of cucurbit[10]uril encapsulation', Journal of the Royal Chemical Society, Dalton Transactions, vol. 42, pp. 8868 - 8877, http://dx.doi.org/10.1039/c3dt50551k

Li F; Feterl M; Mulyana Y; Warner JM; Collins JG; Keene FR, 2012, 'In vitro susceptibility and cellular uptake for a new class of antimicrobial agents: Dinuclear ruthenium(II) complexes', Journal of Antimicrobial Chemotherapy, vol. 67, pp. 2686 - 2695, http://dx.doi.org/10.1093/jac/dks291

Ching HYV; Buck DP; Bhadbhade M; Collins JG; Rendina LM, 2012, 'A ternary supramolecular system containing a boronated DNAmetallointercalator, b-cyclodextrin and the hexanucleotide d(GTCGAC)', Chemical Communications, vol. 48, pp. 880 - 882, http://dx.doi.org/10.1039/c1cc15552k

Li F; Weber DK; Collins JG; Keene FR, 2012, 'An approach to therapeutic agents through selective targeting of destabilised nucleic acid duplex sequences', Journal of the Royal Chemical Society, Dalton Transactions, vol. 41, pp. 6528 - 6535, http://dx.doi.org/10.1039/c2dt12146h

Mulyana Y; Collins JG; Keene FR, 2011, 'Synthesis, nucleic acid binding and cytotoxicity of oligonuclear ruthenium complexes containing labile ligands', Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 71, pp. 371 - 379, http://dx.doi.org/10.1007/s10847-011-0036-1

Mulyana Y; Weber DK; Buck DP; Motti CA; Collins JG; Keene FR, 2011, 'Oligonuclear polypyridylruthenium(ii) complexes incorporating flexible polar and non-polar bridges: Synthesis, DNA-binding and cytotoxicity', Journal of the Royal Chemical Society, Dalton Transactions, vol. 40, pp. 1510 - 1523, http://dx.doi.org/10.1039/c0dt01250e

Li F; Mulyana Y; Feterl M; Warner J; Collins JG; Keene FR, 2011, 'The antimicrobial activity of inert oligonuclear polypyridylruthenium(ii) complexes against pathogenic bacteria, including MRSA', Journal of the Royal Chemical Society, Dalton Transactions, vol. 40, pp. 5032 - 5038, http://dx.doi.org/10.1039/c1dt10250h

Pisani M; Fromm P; Mulyana Y; Clarke RA; Korner H; Heimann K; Collins JG; Keene FR, 2011, 'Mechanism of cytotoxicity and cellular uptake of lipophilic inert dinuclear polypyridylruthenium(II) complexes', Chemmedchem, vol. 6, pp. 848 - 858, http://dx.doi.org/10.1002/cmdc.201100053

Buck DP; Paul JA; Pisani M; Collins JG; Keene FR, 2010, 'Binding of a Flexibly-linked Dinuclear Ruthenium(II)', Australian Journal of Chemistry, vol. 63, pp. 1365 - 1375, http://dx.doi.org/10.1071/CH10065

Pisani M; Weber DK; Heimann K; Collins JG; Keene FR, 2010, 'Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl rutheniunm(II) complexes', Metallomics, vol. 2, pp. 393 - 396, http://dx.doi.org/10.1039/c004922k

Mansour OC; Evison BJ; Sleebs BE; Watson KG; Nudelman A; Rephaeli A; Buck DP; Collins JG; Bilardi RA; Phillips DR; Cutts SM, 2010, 'New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation', Journal of Medicinal Chemistry, vol. 53, pp. 6851 - 6866, http://dx.doi.org/10.1021/jm901894c

Adnan N; Buck DP; Evison B; Cutts SM; Phillips DR; Collins JG, 2010, 'DNA binding by pixantrone', Organic and Biomolecular Chemistry, vol. 8, pp. 5359 - 5366, http://dx.doi.org/10.1039/C0OB00295J

Pisani M; Zhao Y; Wallace L; Woodward CE; Keene FR; Day AI; Collins JG, 2010, 'Cucurbit[10]uril binding of dinuclear platinum(II) and ruthenium(II) complexes: association/dissociation rates from seconds to hours', Journal of the Royal Chemical Society, Dalton Transactions, vol. 39, pp. 2078 - 2086, http://dx.doi.org/10.1039/b921172a

Zhao Y; Pourgholami MH; Morris DL; Collins JG; Day AI, 2010, 'Enhanced cytotoxicity of benzimidazole carbamate derivatives and solubilisation by encapsulation in cucurbit[n]uril', Organic and Biomolecular Chemistry, vol. 8, pp. 3328 - 3337, http://dx.doi.org/10.1039/c003732j